Research Papers

Intramolecularly stapled amphipathic peptides via a boron-sugar interaction

by Monika Kijewska, Angelika Czerwińska, Samah Al-Harthi, Grzegorz Wołczański, Mateusz Waliczek, Abdul-Hamid Emwas, Mariusz Jaremko, Łukasz Jaremko, Piotr Stefanowicz, Zbigniew Szewczuk
Chemical Communications Year: 2020 DOI: 10.1039/d0cc02603d

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Research article


Amadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated into various positions of the peptide chain were investigated using high-resolution mass spectrometry (HR-MS), circular dichroism (CD), and nuclear magnetic resonance (NMR).