Research Papers

Molecular basis of hUHRF1 allosteric activation for synergistic histone modification binding by PI5P
Science Advances Year: 2022 DOI:doi: 10.1126/sciadv.abl9461
Authors: Papita Mandal, Karthik Eswara, Zhadyra Yerkesh, Vladlena Kharchenko, Levani Zandrarashvili, Kacper Szczepski, Dalila Bensaddek, Łukasz Jaremko, Ben E. Black, Wolfgang Fischle
  • hUHRF1
  • Histones
  • PI5P
Lipoic acid restores binding of zinc ions to human serum albumin
Frontiers in Chemistry Year: 2022 DOI:doi.org/10.3389/fchem.2022.942585
Authors: Samah Al-Harthi, Kousik Chandra, Łukasz Jaremko
  • Lipoic Acid
  • zinc(II)
  • fatty acids
  • Human serum albumin (HSA)
  • zinc-binding
  • protein-ligand interactions
  • 2D methyl-TROSY
  • NMR
Metabolomic study on Tridacna maxima giant clams reveals metabolic fingerprint of environmental pollutants
Frontiers in Marine Science Year: 2022 DOI:10.3389/fmars.2022.813404
Authors: Fatimah Almulhim, Susann Rossbach, Abdul-Hamid Emwas, Najeh M. Kharbatia, Lukasz Jaremko, Mariusz Jaremko, Carlos M. Duarte
  • Tridacninae
  • giant clam
  • exogenous and endogenous metabolites
  • 1H NMR
  • GC-MS
  • HPLC-MS
  • marine microplastic investigation
PYK2 senses calcium through a disordered dimerization and calmodulin-binding element
communications biology Year: 2022 DOI:10.1038/s42003-022-03760-8
Authors: Afaque A Momin, Tiago Mendes, Philippe Barthe, Camille Faure, Seungbeom Hong, Piao Yu, Gress Kadaré, Mariusz Jaremko, Jean-Antoine Girault, Łukasz Jaremko, Stefan T Arold
  • PYK2
  • calcium
  • calmodulin
  • NMR
Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis
International Journal of Molecular Sciences Year: 2022 DOI:10.3390/ijms23010551
Authors: Joanna Izabela Lachowicz, Giusi Pichiri, Marco Piludu, Sara Fais, Germano Orrù, Terenzio Congiu, Monica Piras, Gavino Faa, Daniela Fanni, Gabriele Dalla Torre, Xabier Lopez, Kousik Chandra, Kacper Szczepski, Łukasz Jaremko, Mitra Ghosh, Abdul-Hamid Emwas, Massimo Castagnola, Mariusz Jaremko, Ewald Hannappel, Pierpaolo Coni
Research article
  • NMR
  • TEM
  • ferroptosis
  • mRNA
  • metal chelation
  • molecular dynamics
  • thymosine beta 4
Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells
Pharmaceutics Year: 2021 DOI:10.3390/pharmaceutics13060830
Authors: Terenzio Congiu, Mawadda Alghrably, Abdul-Hamid Emwas, Łukasz Jaremko, Joanna Izabela Lachowicz, Marco Piludu, Monica Piras, Gavino Faa, Giuseppina Pichiri, Mariusz Jaremko, Pierpaolo Coni
Research article
  • diabetic nephropathy (DN)
  • metformin
  • copper
  • human islet amyloid polypeptide (hIAPP)
  • metal complexes
Lossen Rearrangement of p-Toluenesulfonates of N-Oxyimides in Basic Condition, Theoretical Study, and Molecular Docking
Frontiers in Chemistry Year: 2021 DOI:10.3389/fchem.2021.662533
Authors: Monika Kijewska, Abeer Sharfalddin, Łukasz Jaremko, Marta Cal, Bartosz Setner, Miłosz Siczek, Piotr Stefanowicz, Mostafa Hussien, Abdul-Hamid Emwas, Mariusz Jaremko
Research article
  • DFT
  • N-oxyimides
  • NMR
  • XRD
  • molecular docking
  • p-toluenesulfonates
Molecular basis for the adaptive evolution of environment-sensing by H-NS proteins
eLife Year: 2021 DOI:10.7554/eLife.57467
Authors: Xiaochuan Zhao, Umar F Shahul Hameed, Vladlena Kharchenko, Chenyi Liao, Franceline Huser, Jacob M Remington, Anand K Radhakrishnan, Mariusz Jaremko, Łukasz Jaremko, Stefan T Arold, Jianing Li
Research article
  • E. coli
  • biochemistry
  • buchnera aphidicola
  • chemical biology
  • computational biology
  • environment-sensing
  • erwinia amylovora
  • evolution
  • idiomarina loiheinsis
  • salmonella typhimurium
  • systems biology
NMR-based metabolomics with enhanced sensitivity
RSC Advances Year: 2021 DOI:10.1039/d1ra01103k
Authors: Kousik Chandra, Samah Al-Harthi, Sujeesh Sukumaran, Fatimah Almulhim, Abdul-Hamid Emwas, Hanudatta S Atreya, Łukasz Jaremko, Mariusz Jaremko
Research article
Genetic and Molecular Factors Determining Grain Weight in Rice
Frontiers in Plant Science Year: 2021 DOI:10.3389/fpls.2021.605799
Authors: Ke Chen, Andrzej Łyskowski, Łukasz Jaremko, Mariusz Jaremko
Review
  • grain size
  • grain weight
  • molecular biotechnology
  • regulatory mechanisms
  • rice
The robust NMR toolbox for metabolomics
Molecular Omics Year: 2021 DOI:10.1039/d1mo00118c
Authors: Kousik Chandra, Samah Al-Harthi, Fatimah Almulhim, Abdul-Hamid Emwas, Łukasz Jaremko, Mariusz Jaremko
Research article
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain
Nature Chemical Biology Year: 2021 DOI:10.1038/s41589-021-00815-5
Authors: Shirish Shukla, Weijiang Ying, Felicia Gray, Yiwu Yao, Miranda L Simes, Qingjie Zhao, Hongzhi Miao, Hyo Je Cho, Paula González-Alonso, Alyssa Winkler, George Lund, Trupta Purohit, EunGi Kim, Xiaotian Zhang, Joshua M Ray, Shihan He, Caroline Nikolaidis, Juliano Ndoj, Jingya Wang, Łukasz Jaremko, Mariusz Jaremko, Russell J H Ryan, Monica L Guzman, Jolanta Grembecka, Tomasz Cierpicki
Research article
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
Molecular Cell Year: 2021 DOI:10.1016/j.molcel.2021.08.034
Authors: Deepanwita Sengupta, Liyong Zeng, Yumei Li, Simone Hausmann, Debopam Ghosh, Gang Yuan, Thuyen N Nguyen, Ruitu Lyu, Marcello Caporicci, Ana Morales Benitez, Garry L Coles, Vladlena Kharchenko, Iwona Czaban, Dulat Azhibek, Wolfgang Fischle, Mariusz Jaremko, Ignacio I Wistuba, Julien Sage, Łukasz Jaremko, Wei Li, Pawel K Mazur, Or Gozani
Research article
  • CRISPR interference mouse model
  • H3K36
  • KRAS
  • MEK inhibition
  • NSD2
  • chromatin
  • epigenetics
  • histone methylation
  • lung adenocarcinoma
  • lung cancer
Elevated NSD3 histone methylation activity drives squamous cell lung cancer
Nature Year: 2021 DOI:10.1038/s41586-020-03170-y
Authors: Gang Yuan, Natasha M Flores, Simone Hausmann, Shane M Lofgren, Vladlena Kharchenko, Maria Angulo-Ibanez, Deepanwita Sengupta, Xiaoyin Lu, Iwona Czaban, Dulat Azhibek, Silvestre Vicent, Wolfgang Fischle, Mariusz Jaremko, Bingliang Fang, Ignacio I Wistuba, Katrin F Chua, Jack A Roth, John D Minna, Ning-Yi Shao, Łukasz Jaremko, Pawel K Mazur, Or Gozani
Research article
Single crystal, Hirshfeld surface and theoretical analysis of methyl 4-hydroxybenzoate, a common cosmetic, drug and food preservative-Experiment versus theory
PLOS ONE Year: 2020 DOI:10.1371/journal.pone.0239200
Authors: Abeer Sharfalddin, Bambar Davaasuren, Abdul-Hamid Emwas, Mariusz Jaremko, Łukasz Jaremko, Mostafa Hussien
Research article
Metal self-assembly mimosine peptides with enhanced antimicrobial activity: towards a new generation of multitasking chelating agents
Dalton Transactions Year: 2020 DOI:10.1039/c9dt04545g
Authors: Joanna Izabela Lachowicz, Gabriele Dalla Torre, Rosita Cappai, Enrico Randaccio, Valeria M. Nurchi, Remigiusz Bachor, Zbigniew Szewczuk, Łukasz Jaremko, Mariusz Jaremko, Maria Barbara Pisano, Sofia Cosentino, Germano Orrù, Antonella Ibba, Joni Mujika, Xabier Lopez
Research article
Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2
Frontiers in Cellular and Infection Microbiology Year: 2020 DOI:10.3389/fcimb.2020.00405
Authors: Intikhab Alam, Allan A Kamau, Maxat Kulmanov, Łukasz Jaremko, Stefan T Arold, Arnab Pain, Takashi Gojobori, Carlos M Duarte
Brief Research Report
  • ARDS (acute respiratory distress syndrome)
  • COVID-19
  • E protein Inhibitors
  • SARS-CoV-2
  • envelope protein (E)
  • therapeutic targets
Hypothesis: Potentially Systemic Impacts of Elevated CO 2 on the Human Proteome and Health
Frontiers in Public Health Year: 2020 DOI:10.3389/fpubh.2020.543322
Authors: Carlos M. Duarte, Łukasz Jaremko, Mariusz Jaremko
Hypothesis and theory article
  • CO2
  • climate-change
  • health
  • human
  • pH
Proteome-level assessment of origin, prevalence and function of leucine-aspartic acid (LD) motifs
Bioinformatics Year: 2020 DOI:10.1093/bioinformatics/btz703
Authors: Tanvir Alam, Meshari Alazmi, Rayan Naser, Franceline Huser, Afaque A Momin, Veronica Astro, Seungbeom Hong, Katarzyna W Walkiewicz, Christian G Canlas, Raphaël Huser, Amal J Ali, Jasmeen Merzaban, Antonio Adamo, Mariusz Jaremko, Lukasz Jaremko, Vladimir B Bajic, Xin Gao, Stefan T Arold
Research article
Examining histone modification crosstalk using immobilized libraries established from ligation-ready nucleosomes
Chemical Science Year: 2020 DOI:10.1039/d0sc03407j
Authors: Diego Aparicio Pelaz, Zhadyra Yerkesh, Sören Kirchgäßner, Henriette Mahler, Vladlena Kharchenko, Dulat Azhibek, Mariusz Jaremko, Henning D Mootz, Łukasz Jaremko, Dirk Schwarzer, Wolfgang Fischle
Research article