Research Papers

Dynamic 15N{1H} NOE measurements: a tool for studying protein dynamics
Journal of Biomolecular NMR Year: 2020 DOI:10.1007/s10858-020-00346-6
Authors: Vladlena Kharchenko, Michal Nowakowski, Mariusz Jaremko, Andrzej Ejchart, Łukasz Jaremko
Research article
  • Dynamic NOE
  • Errors of NOE measurements
  • Heteronuclear NOE
  • NMR
  • Protein dynamics
NMR as a “Gold Standard” Method in Drug Design and Discovery
Molecules Year: 2020 DOI:10.3390/molecules25204597
Authors: Abdul-Hamid Emwas, Kacper Szczepski, Benjamin Gabriel Poulson, Kousik Chandra, Ryan T McKay, Manel Dhahri, Fatimah Alahmari, Łukasz Jaremko, Joanna Izabela Lachowicz, Mariusz Jaremko
  • NMR
  • Drug design
  • drug development
  • drug discovery
  • therapeutics
Using NMR spectroscopy to investigate the role played by copper in prion diseases
Neurological Sciences Year: 2020 DOI:10.1007/s10072-020-04321-9
Authors: Rawiah A Alsiary, Mawadda Alghrably, Abdelhamid Saoudi, Suliman Al-Ghamdi, Łukasz Jaremko, Mariusz Jaremko, Abdul-Hamid Emwas
  • Copper-binding site
  • NMR
  • Neurodegenerative disorder
  • Paramagnetic ions
  • Prion disease
  • Prion protein
  • Protein stability
Copper(II) and Amylin Analogues: A Complicated Relationship
Inorganic Chemistry Year: 2020 DOI:10.1021/acs.inorgchem.9b03498
Authors: Mawadda Alghrably, Dorota Dudek, Abdul-Hamid Emwas, Łukasz Jaremko, Mariusz Jaremko, Magdalena Rowińska-Żyrek
Research article
  • Rodent models
  • Ligands
  • Ions
  • Peptides and proteins
  • Monomers
Intramolecularly stapled amphipathic peptides via a boron-sugar interaction
Chemical Communications Year: 2020 DOI:10.1039/d0cc02603d
Authors: Monika Kijewska, Angelika Czerwińska, Samah Al-Harthi, Grzegorz Wołczański, Mateusz Waliczek, Abdul-Hamid Emwas, Mariusz Jaremko, Łukasz Jaremko, Piotr Stefanowicz, Zbigniew Szewczuk
Research article
Attempting to synthesize lasso peptides using high pressure
PLOS ONE Year: 2020 DOI:10.1371/journal.pone.0234901
Authors: Mateusz Waliczek, Magdalena Wierzbicka, Maciej Arkuszewski, Monika Kijewska, Łukasz Jaremko, Priyadharshni Rajagopal, Kacper Szczepski, Amanda Sroczyńska, Mariusz Jaremko, Piotr Stefanowicz
Research article
De Novo Variants Disrupting the HX Repeat Motif of ATN1 Cause a Recognizable Non-Progressive Neurocognitive Syndrome
American Journal of Human Genetics Year: 2019 DOI:10.1016/j.ajhg.2019.01.013
Authors: Elizabeth E Palmer, Seungbeom Hong, Fatema Al Zahrani, Mais O Hashem, Fajr A Aleisa, Heba M Jalal Ahmed, Tejaswi Kandula, Rebecca Macintosh, Andre E Minoche, Clare Puttick, Velimir Gayevskiy, Alexander P Drew, Mark J Cowley, Marcel Dinger, Jill A Rosenfeld, Rui Xiao, Megan T Cho, Suliat F Yakubu, Lindsay B Henderson, Maria J Guillen Sacoto, Amber Begtrup, Muddathir Hamad, Marwan Shinawi, Marisa V Andrews, Marilyn C Jones, Kristin Lindstrom, Ruth E Bristol, Saima Kayani, Molly Snyder, María Mercedes Villanueva, Angeles Schteinschnaider, Laurence Faivre, Christel Thauvin, Antonio Vitobello, Tony Roscioli, Edwin P Kirk, Ann Bye, Jasmeen Merzaban, Łukasz Jaremko, Mariusz Jaremko, Rani K Sachdev, Fowzan S Alkuraya, Stefan T Arold
  • allelic disorders
  • HX repeat
  • intellectual disability
  • developmental delay
  • dysmorphic
H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing
Nucleic Acids Research Year: 2019 DOI:10.1093/nar/gky1299
Authors: Umar F Shahul Hameed, Chenyi Liao, Anand K Radhakrishnan, Franceline Huser, Safia S Aljedani, Xiaochuan Zhao, Afaque A Momin, Fernando A Melo, Xianrong Guo, Claire Brooks, Yu Li, Xuefeng Cui, Xin Gao, John E Ladbury, Lukasz Jaremko, Mariusz Jaremko, Jianing Li, Stefan T Arold
Research article
NMR Spectroscopy for Metabolomics Research
Metabolites Year: 2019 DOI:10.3390/metabo9070123
Authors: Abdul-Hamid Emwas, Raja Roy, Ryan T McKay, Leonardo Tenori, Edoardo Saccenti, G A Nagana Gowda, Daniel Raftery, Fatimah Alahmari, Lukasz Jaremko, Mariusz Jaremko, David S Wishart
  • GC-MS
  • LC-MS
  • MS
  • NMR
  • analytical platform
  • metabolomics
  • resolution
  • sensitivity
Solid-phase synthesis of peptides containing aminoadipic semialdehyde moiety and their cyclisations
Nature Scientific Reports Year: 2018 DOI:10.1038/s41598-018-28798-9
Authors: Monika Kijewska, Mateusz Waliczek, Marta Cal, Łukasz Jaremko, Mariusz Jaremko, Maria Król, Marta Kołodziej, Marek Lisowski, Piotr Stefanowicz, Zbigniew Szewczuk
Research article
Interaction of amylin species with transition metals and membranes
Journal of Inorganic Biochemistry Year: 2019 DOI:10.1016/j.jinorgbio.2018.11.004
Authors: Mawadda Alghrably, Iwona Czaban, Łukasz Jaremko, Mariusz Jaremko
Focused review
  • Aggregation
  • Aggregation inhibition
  • Amylin
  • Complex formation
  • Diabetes type II
  • Transition metals
Spatial attributes of the four-helix bundle group of bacteriocins - The high-resolution structure of BacSp222 in solution
International Journal of Biological Macromolecules Year: 2017 DOI:10.1016/j.ijbiomac.2017.10.158
Authors: Michał Nowakowski, Łukasz Jaremko, Benedykt Wladyka, Grzegorz Dubin, Andrzej Ejchart, Paweł Mak
Research article
  • BacSp222
  • Four-helix bundle bacteriocins
  • Nuclear magnetic resonance
Towards the functional high-resolution coordination chemistry of blood plasma human serum albumin
Journal of Inorganic Biochemistry Year: 2019 DOI:10.1016/j.jinorgbio.2019.110716
Authors: Samah Al-Harthi, Joanna Izabela Lachowicz, Michał Nowakowski, Mariusz Jaremko, Łukasz Jaremko
Focused review
  • Binding sites
  • Blood plasma
  • Dynamic structures
  • Functional coordination chemistry
  • Human serum albumin (HSA)
  • Transition metal ions
Fast evaluation of protein dynamics from deficient 15N relaxation data
Journal of Biomolecular NMR volume Year: 2018 DOI:10.1007/s10858-018-0176-3
Authors: Łukasz Jaremko, Mariusz Jaremko, Andrzej Ejchart, Michał Nowakowski
  • 15N magnetic relaxation
  • Protein dynamics
  • Model-free approach
  • Ratio, product, and difference of relaxation rates
  • Semi-quantitative analysis of 15N relaxation data